Study programme 2020-2021Français
General Toxicology
Programme component of Bachelor's in Biomedical Sciences à la Faculty of Medicine and Pharmacy

Students are asked to consult the ECTS course descriptions for each learning activity (AA) to know what special Covid-19 assessment methods are possibly planned for the end of Q3

CodeTypeHead of UE Department’s
contact details
UM-B3-BIOMED-001-MCompulsory UECOLET Jean-MarieM125 - Biologie humaine et Toxicologie
  • COLET Jean-Marie

of instruction
of assessment
HT(*) HTPE(*) HTPS(*) HR(*) HD(*) CreditsWeighting Term
  • Anglais
Anglais30000033.001st term

AA CodeTeaching Activity (AA) HT(*) HTPE(*) HTPS(*) HR(*) HD(*) Term Weighting
M-BHTO-304General toxicology300000Q1100.00%
Programme component

Objectives of Programme's Learning Outcomes

  • Understand, describe, analyse and prioritise biological phenomena
    • Understand basic scientific knowledge and be able to use it
    • Problem-solve
    • Understand the expression of biological realities in absolute or relative terms, the orders of magnitude, proportions and probability
    • Abstract, understand and apply mathematical translations of the main laws and biological phenomena
    • Understand and use different graphical representations of numerical values and their relationships
    • Perceive spatial distribution, and understand two- and three-dimensional representations and interconvert them
    • Understand the chronology of a phenomenon and master the time scales and their representations
  • Control the molecular, morphological and functional approaches of normal and pathological conditions
    • Understand the learning of physiological and pharmacological reasoning
    • Understand experimental protocols in the biomedical domain
    • Integrate concepts from different approaches/disciplines in a complex biomedical problem
    • Explain how molecular, morphological and functional modifications constitute pathological states and vice versa
  • Develop reasoning skills
    • Understand and apply the basic principles of reasoning (obtaining data, analysis, synthesis, comparison, the rule of three, syllogism, analogy, Boolean logic, etc.)
    • Understand the statistical and/or epidemiological methods
    • Work with efficiency / accuracy / precision
  • Demonstrate developed interpersonal skills
    • Use a rich vocabulary linking concepts and words accurately
    • Adapt lexical and syntactic choices in communication register (everyday language, medical language or scientific terminology)
    • Summarise, explain, and argue
    • Share knowledge and information
    • Submit reviews, reports and give oral presentations
  • Manage resources
    • Manage time
    • Prioritise
    • Use basic IT and bibliographic resources.
  • Manage their studies
    • Locate scientific information efficiently
    • Compare different sources of information
    • Read, interpret, and critique a scientific article
    • Be open to research and demonstrate scientific curiosity
  • Show a good knowledge of scientific English
    • Understand and summarise a scientific article in English

Learning Outcomes of UE

At the end of this course, the students will be able to :

- describe the different phases of the biotransformation of toxicants
- explain the bioactivation process and its role in toxicology
- define and explain the major toxicological concepts (target organ, dose, mode of action, ...)
- descrobe the conventional procedures of risk assessment
- describe the main mechansims of toxicity of chemicals ( for example oxuidative stress, disruption of calcium homeostasis, alteration in cell proliferation during tissue repair)
- differenciate and explain the mechanisms of necrosis and apoptosis
- explain the importnace of covalent binding of chemicals to macromolecules
- describe the mechanisms of immunotoxicity and enzymes inactivation
- Understand the role of nuclear receptors and signalling pathways in toxic mechanisms

Content of UE

1. Concepts in ADME (Administration, Distribution, Metabolism, Elimination)

2. Biotransformation and bioactivation of chemicals

3. Modulators of toxic effetcs

4. Conventional procedures of risk assessment

5. Major toxic mechanisms (oxidative stress, disruption of calcium homeostasis, necrosis and apoptosis, cell proliferaiton, covanlent binding to macromolecules, immunotoxicity, enzymes inactivation, interaction with ionic transporters)

Prior Experience

Fundamentals in biology and chemistry

Type of Assessment for UE in Q1

  • Written examination
  • eTest

Q1 UE Assessment Comments

Not applicable

Type of Assessment for UE in Q3

  • Written examination
  • eTest

Q3 UE Assessment Comments

Not applicable

Type of Resit Assessment for UE in Q1 (BAB1)

  • N/A

Q1 UE Resit Assessment Comments (BAB1)

Not applicable

Type of Teaching Activity/Activities

AAType of Teaching Activity/Activities
  • Cours magistraux
  • Projet sur ordinateur
  • Etudes de cas

Mode of delivery

AAMode of delivery
  • Mixed

Required Reading


Required Learning Resources/Tools

AARequired Learning Resources/Tools
M-BHTO-304Not applicable

Recommended Reading


Recommended Learning Resources/Tools

AARecommended Learning Resources/Tools
M-BHTO-304Sans objet

Other Recommended Reading

AAOther Recommended Reading
M-BHTO-304Not applicable

Grade Deferrals of AAs from one year to the next

AAGrade Deferrals of AAs from one year to the next
(*) HT : Hours of theory - HTPE : Hours of in-class exercices - HTPS : hours of practical work - HD : HMiscellaneous time - HR : Hours of remedial classes. - Per. (Period), Y=Year, Q1=1st term et Q2=2nd term
Date de génération : 09/07/2021
20, place du Parc, B7000 Mons - Belgique
Tél: +32 (0)65 373111