Objectives of Programme's Learning Outcomes

Learning Outcomes of UE

The main objective of this course is to provide to the students the major tools used to predict the potential toxic effects of chemicals.  Consequently, at the end of this course, the students will be able to :

-  understand and describe the predictive approach based on structure-activity relationship (QSAR)

- Use the available predictive softwares for the prediction of the metabolism and the safety of a substance from its chemical structure

- identify the most appropriate in vitro and in vivo assays for risk assessment based on the target organ

- interprete data obtained from the mandatory Ames assay

- design a study protocol for preclinical toxicology evaluation 
 

UE Content: description and pedagogical relevance

The class will be divided in two sections:

1. in silico Models (QSAR, CADD, and expert systems)

2. in vitro et in vivo models (mutagenicity, developmental toxicity, major target organs, and genomics, proteomics, and metabonomics approaches applied to toxcicology)

Prior Experience

Fundamentals in biology and chemistry
Genral toxicology class

Type(s) and mode(s) of Q2 UE assessment

• Written examination - Face-to-face

Q2 UE Assessment Comments

For Part I (AA QSAR approaches), the exam is composed of two parts (with a score of 10 points):
1) a series of 20 MCQs (quote on 5 points)
2) an open question (quote on 5 points)

For part II (in vitro and in vivo tests), the overall score of the AA out of 10 points is calculated as follows:
1) 4 points out of 10 are attributed to the eaxm on TPs
2) 6 points out of 10 for a series of 12 MCQs

 

Method of calculating the overall mark for the Q2 UE assessment

The overall EU score is calculated as the arithmetic sum of the scores obtained in the two AAs. In case of failure (overall mark

Type(s) and mode(s) of Q3 UE assessment

• Written examination - Face-to-face

Q3 UE Assessment Comments

same as Q2

Method of calculating the overall mark for the Q3 UE assessment

same as Q2