Objectives of Programme's Learning Outcomes

Learning Outcomes of UE

The main objective of this course is to provide to the students the major tools used to predict the potential toxic effects of chemicals.  Consequently, at the end of this course, the students will be able to :

-  understand and describe the predictive approach based on structure-activity relationship (QSAR)

- Use the available predictive softwares for the prediction of the metabolism and the safety of a substance from its chemical structure

- identify the most appropriate 

- interprete data obtained from the mandatory Ames assay

- design a study protocol for preclinical toxicology evaluation 
 

UE Content: description and pedagogical relevance

The class will be divided in two sections:

1. QSAR, CADD, and expert systems)

2. Models to predict mutagenicity of chemicals + hERG assay

Prior Experience

Fundamentals in biology and chemistry
Genral toxicology class

Type(s) and mode(s) of Q2 UE assessment

• Written examination - Face-to-face
• Production (written work, report, essay, collection, product, etc.) - To be submitted online

Q2 UE Assessment Comments

For Part I (AA QSAR approaches), the exam is composed of two parts (with a score of 10 points):
1) a series of 20 MCQs (quote on 5 points)
2) an open question (quote on 5 points)

For part II (in vitro and in vivo tests), the overall score of the AA out of 10 points is calculated as follows:
1) 4 points out of 10 are attributed to the exam and reports on practicals
2) 6 points out of 10 are attributed either to a group work (related to the integration of all concepts covered during classes and practicals) or to a series of MCQs

 

Method of calculating the overall mark for the Q2 UE assessment

The overall EU score is calculated as the arithmetic sum of the scores obtained in the two AAs. In case of failure (overall mark), both parts have to be reevaluated

Type(s) and mode(s) of Q3 UE assessment

• Written examination - Face-to-face

Q3 UE Assessment Comments

same as Q2

Method of calculating the overall mark for the Q3 UE assessment

same as Q2