Objectives of Programme's Learning Outcomes

• Conduct extensive research and development projects related to biological sciences, in biochemistry and in molecular and cell biology.
• Apply, mobilise, articulate and promote the knowledge and skills acquired in order to help lead and complete a project.
• Show initiative and be able to work independently and in teams.
• Manage and lead research, development and innovation projects.
• Methodically research valid scientific information, critically analyse, propose and argue potentially innovative solutions to targeted problems.
• Master communication techniques.
• Communicate, both orally and in writing, their findings, original proposals, knowledge and underlying principles, in a clear, structured and justified manner.
• Adapt their communication to a variety of audiences.
• Master the techniques of written and oral scientific communication in both French and English.
• Develop and integrate a high degree of autonomy.
• Aquire new knowledge independently.
• Pursue further training and develop new skills independently.
• Apply scientific methodology.
• Critically reflect on the impact of their discipline in general, and on the contribution to projects.

Learning Outcomes of UE

The course on industrial biotechnology introduction enables students to acquire the following knowledge:
- Represent enzymatic and microbial reactions through appropriate kinetic laws;
- Understand and use the basics of engineering bioprocesses and biorefineries;
- Understand the complexity of extrapolating a process from a laboratory to a driver and then to an industry;
- Understand online monitoring and regulation problems
- Choose a method of separation / purification based on the constraints

UE Content: description and pedagogical relevance

This course is divided into parts.
A general introduction concerning the exploitation of biomass as a renewable resource and the progressive conversion of refineries into biorefineries is proposed.
Some legal and normative concepts are taught (contained use, security level laboratories).
The biocatalysis and bioreactor aspects are then discussed by the characterisation of the mechanisms (enzymatic and microbial biocatalysis), and engineering microbial bioreactors (flows, continuous reactors, batch, fed-batch, airlift, the balance sheets of materials, heat exchanges). Associated with these descriptions, scale up problems and monitoring of processes are presented. Some examples of models such as metabolic fluxes, structured models, macroscopic models are detailed.
The purification aspects (membranes, chromatography, precipitation, etc.) are then discussed in the light of the final use of bioproduct. Some examples of major industrial bioprocesses are described (antibodies, vaccines, bioethanol, biogas, treatment of urban waters).

Prior Experience

Organic Chemistry basic concepts (structure, function, spatial representations), cellular metabolism and cellular physiology and basic laboratory techniques (analytical and organic chemistry) are required to follow this course unit.