Objectives of Programme's Learning Outcomes

• In the field of biological sciences and particularly in the field of the biochemistry, molecular and cell biology, possess highly specialised and integrated knowledge and a wide range of skills adding to those covered in the Bachelor's programme in biological sciences.
• Manage and lead research, development and innovation projects.
• Understand unprecedented problems in biological sciences, and more specifically in biochemistry and molecular and cell biology and its applications.
• Methodically research valid scientific information, critically analyse, propose and argue potentially innovative solutions to targeted problems.
• Master communication techniques.
• Communicate, both orally and in writing, their findings, original proposals, knowledge and underlying principles, in a clear, structured and justified manner.
• Develop and integrate a high degree of autonomy.
• Aquire new knowledge independently.
• Pursue further training and develop new skills independently.

Learning Outcomes of UE

The main objective of this course is to provide to the students the major tools uise di the rediciton of potektail toxic effects of chemicals.  Consequently, at the end of this course, the students will be able to :

-  understand and describe the predictive approach based on structure-activity relationship (QSAR)

- Use predictive softwares (Meteor and Derek) for the prediction of the metabolism and the safety of a substance from its chemical structure

- identify the most appropriate in vitro and in vivo assays to assess the mutagenic risk of chemicals

- interprete data obtained with the Ames assay

- design a study protocol for preclinical toxicology evaluation 
 

UE Content: description and pedagogical relevance

After a short introduction on the basic concepts in toxicology, the course will be divided into two sections:

1. in silico Models /QSAR

2. in vitro et in vivo Models (mutagenicity)

 

Prior Experience

Fundamentals in biology and chemistry

Type(s) and mode(s) of Q2 UE assessment

• Written examination - Face-to-face
• Production (written work, report, essay, collection, product, etc.) - To be submitted in class

Q2 UE Assessment Comments

Multiple choice questions
Open questions
Reports + Exam on Practicals

Method of calculating the overall mark for the Q2 UE assessment

Part I (QSAR approaches) on 10 points:
1) A series of 20 MCQs ( / 5 points)
2) An open question ( / 5 points)

Part II (in vitro and in vivo tests) out of 10 points
1) A series of 12 MCQs on the theoretical part ( / 6 points)
2) Question on the TPs ( /4 points)

The overall mark of the UE is the sum of the marks obtained for the 2 AAs (parts I and II). In case of failure (global note), the student will be reevaluated on both parts of the course

Type(s) and mode(s) of Q3 UE assessment

• Written examination - Face-to-face
• Production (written work, report, essay, collection, product, etc.) - To be submitted in class

Q3 UE Assessment Comments

same as Q2

Method of calculating the overall mark for the Q3 UE assessment

same as Q2